Projects
Ongoing primary projects in the Molecular Diagnostic and Clinical Research Group
Personalised medication is the key in all our projects. Our methods are centred around assessment of patients with inflammatory diseases, but reach widely across professions, disciplines and study designs. Our projects are conducted in collaboration with research teams both nationally and internationally.
Our ambition is to improve the treatment for every individual patient regardless of disease course and lifestyle. The treatment is improved if e.g. the diagnosis is correct the first time, if the treatment is timed correctly, or if the right medication is used from first day of treatment. Unfortunately, for more than half the patients, that is not currently the case.
Selected research areas
- Uderstanding of the disease mechanisms
- Prediction of treatment response
- Register studies and dietary influences
- Chronic inflammatory diseases (inflammatory bowel disease, rheumatic conditions, and inflammatory skin conditions)
- Colon cancer
Ongoing primary projects
Gluten-UC
A randomised controlled dietary trial assessing the effect of gluten intake on gastrointestinal symptoms and fatigue in patients with Ulcerative Colitis planned to be conducted in 2024. The study further aims to identify clinical and biological characteristics of those who benefit from a gluten free diet.
Contact: Laura Gregersen
BELIEVE
A prospective cohort study of prognostic factors and personalized medicine in chronic inflammatory diseases. The study aims to identify lifestyle factors and biomarkers that may improve the outcome of targeted therapy.
Contact: Vibeke Andersen
TARCID
The study aims to predict the outcome of targeted therapy in chronic inflammatory diseases. Results will be based on genetic analysis of more than 11.000 patients and 100.000 controls in the search for molecular markers that can predict the effect of therapy in the individual patient.
Contact: Vibeke Andersen
TWIBD
A study of identical twins whereof one has inflammatory bowel disease and mouse models with fecal transplantation from the twins. The aim is to understand the interaction between diet, gut microbes and disease mechanisms. The study is characterizing the metagenome and metabolome of the gut and saliva in inflammatory bowel disease.
Contact: Vibeke Andersen
NORDTREAT
A clinical study evaluating a biomarker aimed at stratifying Inflammatory Bowel Disease patients according to their need for intensive medical treatment.
Contact: Anja Severino
IBD-R (registry)
Examination of the registered information behind decisions on treatment in inflammatory bowel disease, i.e. which data regarding diagnosis, treatment decisions, treatment shift etc. is available for clinicians when making decisions on personalised medicine? The project is also aiming to combine clinical information with investigations on biological material.
Contact: Nathalie Fogh Rasmussen